The function of active oxygen, lactoferrin and fluoride is supported by scientific research. Naturally this contributes to the justification of particular ingredients in the Implaclean formula. New and relevant research for the product implaclean and its ingredients will be posted on this page.

Science on Active oxygen Ardox-X

The active oxygen Ardox-X contributes to a healing effect for treating peri-implantitis and periodontitis.
J.L.M. Berendsen, I. el Allati, L.H. Sylva, P.A. Blijdorp, P.h.A van Damme, G.J. Meijer: Ardox-X® adjunctive topical active oxygen application in periodontitis and peri-implantitis. Click here

Ardox-X helps prevent and treat oral malodor. The research shows the effect of Corsodyl and Ardox-X for treating oral malodor. Corsodyl contains chlorhexidine, which works as disinfectant and helps cure oral malodor. However, if used regularly, it causes side effects like pain and swellings. Ardox-X exhibits good results, just like Corsodyl, yet without the negative side effects.
M. Grootveld: A multifactorial investigation of the ability of oral healthcare products to combat oral malodor. Click here

Chlorhexidine is used in mouth-water and oral-gels to combat bacteria. Research shows, that chlorhexidine behaves as a toxic for cells and function of mitochondrion. Ardox-X also combats bacteria, but will only target the bad bacteria. This explains why Ardox-X does not exhibit negative side-effects. M. Gianelli: Effect of chlorhexidine digluconate on different cell types. Click here

Ardox-X also combats plaque

Ardox-X also combats plaque. The effects of Ardox-X on the composition of oral bacteria has been researched. This shows that the bacteria are inhibited and that the composition of plaque has been improved. This results in better oral hygiene.
Mercedes Fernandez y Mostajo, Wil A. van der Reijden, Mark J. Buijs, Wouter Beertsen, Fridus van der Weijden, Wim Crielaard and Egija Zaura: Effect of an oxygenating agent on oral bacteria in vitro and on dental plaque composition in healthy young adults. Click here

Lactoferrin in science

Lactoferrin works as a promoter of bone cells and improves and increases bone formation. Dental implants needs to attach itself to the natural bone. This makes lactoferrin a fine addition to the ingredients of an implant toothpaste.
J.Cornish, K.E. Callon, D. Naot: Lactoferrin is a potent regulator of bone cell activity and increases bone format. Click here

Influences on titanium

For the cleaning of dental implants, the use of a toothpaste without abrasives and minimal fluoride is important. Research shows that fluoride concentrations above 500 ppm can affect and damage the implant.
M. Nakagawa, S. Matsuya, T. Shiraishi and M. Otha: Effect of fluoride and pH on Titanium. Click here 

The pH-value can also affect the implant in combination with fluoride. It is found that fluoride will damage titanium if the pH-value is below neutral. G.Boere: Effect of fluoride in an acidic environment. Click here